The different routes of calcium efflux from liver mitochondria.

Abstract

Calcium efflux from liver mitochondria, induced by an uncoupler during incubation at 20 degrees C, is largely inhibited by the prior addition of ruthenium red or EGTA. The inhibition by EGTA (i.e. by chelation of Ca2+) is impaired by the presence of EDTA (i.e. by chelation of Mg2+), and it is completely abolished by addition of spermine. In contrast, the… (More)

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