The different roles of ER subtypes in cancer biology and therapy

  title={The different roles of ER subtypes in cancer biology and therapy},
  author={Christoforos Thomas and Jan-Ake Gustafsson},
  journal={Nature Reviews Cancer},
By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in… CONTINUE READING
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Combined analysis of estrogen receptor β-1 and progesterone receptor expression identifies lung cancer patients with poor outcome

  • Stabile, P L.
  • Clin. Cancer Res. 17,
  • 2011

Dietary-induced ERβ upregulation counteracts intestinal neoplasia development in intact male ApcMin/+ mice

  • M Barone
  • Carcinogenesis 31,
  • 2010

ER β impedes prostate cancer EMT by destabilizing HIF - 1 α and inhibiting VEGFmediated snail nuclear localization : implications for Gleason grading

  • P. Mak
  • Cancer Cell
  • 2010

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