The different roles of ER subtypes in cancer biology and therapy

@article{Thomas2011TheDR,
  title={The different roles of ER subtypes in cancer biology and therapy},
  author={Christoforos Thomas and Jan-Ake Gustafsson},
  journal={Nature Reviews Cancer},
  year={2011},
  volume={11},
  pages={597-608}
}
By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ exert opposite effects on cellular processes that include proliferation, apoptosis and migration and that differentially influence the development and the progression of cancer. Perturbation of ER subtype-specific expression has been detected in various types of cancer, and the differences in the expression of ERs are correlated with the clinical outcome. The changes in the bioavailability of ERs in… CONTINUE READING
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