The different faces of Notch in T-helper-cell differentiation

  title={The different faces of Notch in T-helper-cell differentiation},
  author={Derk Amsen and Andrey N Antov and Richard A Flavell},
  journal={Nature Reviews Immunology},
Interleukin-12 (IL-12) and IL-4 induce T helper 1 (TH1)- and TH2-cell differentiation, respectively, in vitro. However, not all TH1-cell responses require IL-12 in vivo, and TH2-cell responses are remarkably independent of IL-4-receptor signalling, suggesting that other polarizing signals must exist. Accumulating evidence indicates that Notch is a candidate receptor that might mediate these signals. However, contrasting roles for Notch have been proposed: some evidence shows that Notch promotes… CONTINUE READING
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