The different extent of B and T cell immune reconstitution after hematopoietic stem cell transplantation and enzyme replacement therapies in SCID patients with adenosine deaminase deficiency.

@article{Serana2010TheDE,
  title={The different extent of B and T cell immune reconstitution after hematopoietic stem cell transplantation and enzyme replacement therapies in SCID patients with adenosine deaminase deficiency.},
  author={Federico Serana and Alessandra Sottini and Marco Chiarini and Cinzia Zanotti and Claudia Ghidini and Arnalda Lanfranchi and Lucia Dora Notarangelo and Luigi Caimi and Luisa Imberti},
  journal={Journal of immunology},
  year={2010},
  volume={185 12},
  pages={
          7713-22
        }
}
The lack of adenosine deaminase (ADA) leads to the accumulation of toxic metabolites, resulting in SCID. If the disease is left untreated, it is likely to have a fatal outcome in early infancy. Because hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy with pegylated bovine ADA (PEG-ADA) are both provided in our hospital, we undertook a retrospective longitudinal comparative study of the extent of lymphocyte recovery in two groups of treated ADA-SCID children… CONTINUE READING
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