The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death

@article{Bonaf2004TheDA,
  title={The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death},
  author={Massimiliano Bonaf{\'e} and Stefano Salvioli and Cristiana Barbi and Chiara Trapassi and Francesca Tocco and Gianluca Storci and Laura Invidia and Ivan Vannini and Matteo Rossi and Erika Marzi and Michele Mishto and Miriam Capri and Fabiola Olivieri and Roberto Antonicelli and Maurizio Memo and Daniela Letizia Uberti and Benedetta Nacmias and Sandro Sorbi and Daniela Monti and Claudio Franceschi},
  journal={Cell Death and Differentiation},
  year={2004},
  volume={11},
  pages={962-973}
}
AbstractA common arginine to proline polymorphism is harboured at codon 72 of the human p53 gene. In this investigation, we found that fibroblasts and lymphocytes isolated from arginine allele homozygote centenarians and sexagenarians (Arg+) undergo an oxidative-stress-induced apoptosis at a higher extent than cells obtained from proline allele carriers (Pro+). At variance, the difference in apoptosis susceptibility between Arg+ and Pro+ is not significant when cells from 30-year-old people are… CONTINUE READING

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Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress

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  • Proc. Natl. Acad. Sci. USA
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