The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B.

@article{Bierhaus1997TheDP,
  title={The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B.},
  author={Angelika Bierhaus and Yingjia Zhang and Peter Quehenberger and Thomas Luther and Michael Haase and Markus S. Mueller and Nigel Mackman and Reinhard Ziegler and Peter P Nawroth},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={77 4},
  pages={772-82}
}
The natural occurring pigment curcumin, a major component of the spice tumeric, has been described to have antioxidative, anti-tumorpromoting, anti-thrombotic and anti-inflammatory properties. It appears, that the pleiotropic effects of curcumin are at least partly due to inhibition of the transcription factors NF-kappa B and AP-1. This study investigates the effect of curcumin on the TNF alpha induced expression of endothelial Tissue Factor (TF), the central mediator of coagulation known to be… CONTINUE READING

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