The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-beta phosphorylation.

@article{Lamy2008TheDF,
  title={The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-beta phosphorylation.},
  author={S. Lamy and Val{\'e}rie B{\'e}dard and David R. Labbe and Herv{\'e} Sartelet and Chantal Barthomeuf and D. F. Gingras and Richard B{\'e}liveau},
  journal={Cancer prevention research},
  year={2008},
  volume={1 6},
  pages={
          452-9
        }
}
Platelet-derived growth factor (PDGF)-dependent recruitment of mural cells such as pericytes and smooth muscle cells plays a central role in the maturation and stabilization of newly formed vasculature during angiogenesis. In this work, we show that the dietary flavones apigenin and luteolin may interfere with this event through their inhibitory effect on PDGF-dependent phosphorylation of PDGF receptor beta (PDGFR-beta) in smooth muscle cells. Inhibition of PDGFR-beta activity by apigenin and… CONTINUE READING

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