The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury

@article{Yamada1998TheDD,
  title={The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury},
  author={K. A. Yamada and Douglas F. Covey and C. Y. Hsu and Rong Hu and Y Hu and Y. Y. He},
  journal={Annals of Neurology},
  year={1998},
  volume={43}
}
The diazoxide derivative IDRA 21 and other positive modulators of (AMPA)‐type glutamate receptors are considered potential memory‐enhancing agents. However, AMPA receptor activation contributes to CA1 hippocampal neuron damage from global ischemia in rodents, raising the possibility that 7‐chloro‐3‐methyl‐3‐4‐dihydro‐2H‐1,2,4 benzothiadiazine S, S‐dioxide (IDRA 21) or drugs with similar actions may worsen ischemic neuronal injury. Here we demonstrate that glutamate plus IDRA 21 kills cultured… 

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