The diamidine DB75 targets the nucleus of Plasmodium falciparum

@article{Purfield2008TheDD,
  title={The diamidine DB75 targets the nucleus of Plasmodium falciparum},
  author={Anne E Purfield and R. Richard Pittsboro Tidwell and Steven R. Meshnick},
  journal={Malaria Journal},
  year={2008},
  volume={8},
  pages={104 - 104}
}
BackgroundDB289, [2,5-bis(4-amidinophenyl)furan bis-O-methylamidoxime], is a broad spectrum anti-parasitic compound which has been shown to be effective against malaria in recent clinical trials. DB75, [2,5-bis(4-amidinophenyl)furan], is the active metabolite of this drug. The objective of this study was to determine the mechanism of action of DB75 in Plasmodium falciparum.MethodsLive parasites were observed by confocal microscopy after treatment with organelle specific dyes and DB75, an… CONTINUE READING

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