The diagnosis and clinical significance of polyautoimmunity.

  title={The diagnosis and clinical significance of polyautoimmunity.},
  author={Juan-Manuel Anaya},
  journal={Autoimmunity reviews},
  volume={13 4-5},
Autoimmune diseases (ADs) are chronic and heterogeneous conditions that affect specific target organs or multiple organ systems. The chronic nature of these diseases places a significant burden on the utilization of medical care, direct and indirect economic costs, and quality of life. ADs are observed in genetically susceptible individuals in whom their clinical expression is modified by permissive and protective environments occurring over time. These are complex traits, meaning that their… CONTINUE READING

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