The diacylglycerol kinase eta gene and bipolar disorder: a replication study in a Sardinian sample

@article{Squassina2009TheDK,
  title={The diacylglycerol kinase eta gene and bipolar disorder: a replication study in a Sardinian sample},
  author={Alessio Squassina and Mirko Manchia and Donatella Congiu and Giovanni Severino and Caterina Chillotti and Raffaella Ardau and Mariapaola Piccardi and Maria Del Zompo},
  journal={Molecular Psychiatry},
  year={2009},
  volume={14},
  pages={350-351}
}
Diacylglycerol kinase eta (DGKH) is a key enzyme involved in the regulation of the phosphatidyl inositol pathway. DGKH is located in 13q14, a region in linkage with bipolar disorder (BD). A genomewide association study (GWAS) published in this journal reported strong association between three single nucleotide polymorphisms (SNPs) located in the first intron of DGKH and bipolar disorder I (BDI) in two independent samples. In the attempt to replicate previous findings, we carried out an… CONTINUE READING