The diabetes gene Hhex maintains δ-cell differentiation and islet function.

Abstract

The homeodomain transcription factor HHEX (hematopoietically expressed homeobox) has been repeatedly linked to type 2 diabetes mellitus (T2DM) using genome-wide association studies. We report here that within the adult endocrine pancreas, Hhex is selectively expressed in the somatostatin-secreting δ cell. Using two mouse models with Hhex deficiency in the… (More)
DOI: 10.1101/gad.235499.113

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