The developmental regulators, FlbB and FlbE, are involved in the virulence of Aspergillus fumigatus.

  title={The developmental regulators, FlbB and FlbE, are involved in the virulence of Aspergillus fumigatus.},
  author={Sung-Su Kim and Young Hwan Kim and Kwang-Soo Shin},
  journal={Journal of microbiology and biotechnology},
  volume={23 6},
Several upstream activators required for proper activation of brlA are involved in the development, vegetative growth, toxin production, and pathogenesis of Aspergillus fumigatus. In this study, we characterized the roles of two upstream developmental regulators, A. fumigatus flbB (AfuflbB) and flbE (AfuflbE), in toxin production and virulence. The deletion of AfuflbB and AfuflbE resulted in reduction of the expression of AfulaeA. Moreover, only about 8% to 10% of fumagillin was produced in the… 

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