The developmental regulators, FlbB and FlbE, are involved in the virulence of Aspergillus fumigatus.

@article{Kim2013TheDR,
  title={The developmental regulators, FlbB and FlbE, are involved in the virulence of Aspergillus fumigatus.},
  author={Sung-Su Kim and Young Hwan Kim and Kwang-Soo Shin},
  journal={Journal of microbiology and biotechnology},
  year={2013},
  volume={23 6},
  pages={
          766-70
        }
}
Several upstream activators required for proper activation of brlA are involved in the development, vegetative growth, toxin production, and pathogenesis of Aspergillus fumigatus. In this study, we characterized the roles of two upstream developmental regulators, A. fumigatus flbB (AfuflbB) and flbE (AfuflbE), in toxin production and virulence. The deletion of AfuflbB and AfuflbE resulted in reduction of the expression of AfulaeA. Moreover, only about 8% to 10% of fumagillin was produced in the… 
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References

SHOWING 1-10 OF 21 REFERENCES

Characterization of the developmental regulator FlbE in Aspergillus fumigatus and Aspergillus nidulans.

FlbC is a putative nuclear C2H2 transcription factor regulating development in Aspergillus nidulans

FlbC is a putative nuclear transcription factor necessary for proper activation of conidiation, and its balanced activity is crucial for governing growth and development in A. nidulans.

Aspergillus fumigatus flbB Encodes Two Basic Leucine Zipper Domain (bZIP) Proteins Required for Proper Asexual Development and Gliotoxin Production

Northern blot analyses reveal that both AfuFlbB and AfuflbE are necessary for expression of Afu flbD, suggesting that FlbD functions downstream of FlbB/FlbE in aspergilli.

The bZIP‐type transcription factor FlbB regulates distinct morphogenetic stages of colony formation in Aspergillus nidulans

The combined evidence points to FlbB as a key factor in the transition to asexual development, playing a role at various control points in which the process could be reversed.

Regulation of Aspergillus Conidiation

This chapter discusses our current understanding of how conidiation in Aspergillus is regulated, with emphasis on the model fungus A. nidulans. The three genes (brlA, abaA, and wetA) have been…

LaeA, a Regulator of Secondary Metabolism in Aspergillus spp

A novel Aspergillus nuclear protein, LaeA, is presented here as a global regulator of secondary metabolism in this genus, and strains show little difference in spore production compared to the wild type, indicating that the primary role of laeA is to regulate metabolic gene clusters.

LaeA, a Regulator of Morphogenetic Fungal Virulence Factors

It is shown that an A. fumigatus mutation in a developmentally expressed transcriptional regulator (ΔlaeA) coordinating morphological and chemical differentiation reduces virulence in a murine model; impaired virulence is associated with decreased levels of pulmonary gliotoxin and multiple changes in conidial and hyphal susceptibility to host phagocytes ex vivo.

Genetic requirements for initiating asexual development in Aspergillus nidulans

It is proposed that there are multiple mechanisms for activating brlA, a well-characterized transcriptional regulator of genes that are induced specifically during asexual development, and complex hierarchical relationships among these loci are discussed.

Asexual Sporulation in Aspergillus nidulans

A working model is presented in which the regulatory interactions between these two pathways during the fungal life cycle determine whether cells grow or develop.

Secondary metabolic gene cluster silencing in Aspergillus nidulans

It is shown that LaeA regulation does not extend to nutrient utilization or the spoC1 sporulation clusters in Aspergillus nidulans.