The developmental expression profile of PAX2 in the murine prostate.

@article{Chen2010TheDE,
  title={The developmental expression profile of PAX2 in the murine prostate.},
  author={Qian Chen and David J Degraff and Robert A. Sikes},
  journal={The Prostate},
  year={2010},
  volume={70 6},
  pages={654-65}
}
BACKGROUND Nine transcription factors comprise the PAX gene family that regulate organogenesis. The urogenital system of PAX2 null male mice fails to develop properly. PAX2 is overexpressed in PC3 cells. Therefore, PAX2 is implicated in both prostate organogenesis and cancer. However, the expression pattern/profile of PAX2 in the prostate is unknown. METHODS PAX2/5/8 expression was surveyed in E16.5 male urogenital sinus (UGS) by RT-PCR. Prostate samples from 10 developmental stages in C3H… CONTINUE READING
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