The developmental expression of cell cycle regulators in Xenopus laevis.

@article{Vernon2003TheDE,
  title={The developmental expression of cell cycle regulators in Xenopus laevis.},
  author={Ann E. Vernon and Anna Philpott},
  journal={Gene expression patterns : GEP},
  year={2003},
  volume={3 2},
  pages={179-92}
}
Several cyclins and cdks have been cloned in Xenopus, but their developmental expression has not been thoroughly examined. We have analyzed the temporal and spatial expression of cdk1, cdk2, cdk4 and cyclins D1, D2, E, A1, A2 and B1 by in situ hybridization. The transcripts of these cyclins and cdks exhibit striking tissue-restricted expression patterns very early in development that cannot be strictly correlated with proliferation. While the cdks and their activating cyclins are expressed in… CONTINUE READING

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