The developmental control of transposable elements and the evolution of higher species.

@article{Friedli2015TheDC,
  title={The developmental control of transposable elements and the evolution of higher species.},
  author={Marc Friedli and Didier Trono},
  journal={Annual review of cell and developmental biology},
  year={2015},
  volume={31},
  pages={429-51}
}
Transposable elements (TEs) account for at least 50% of the human genome. They constitute essential motors of evolution through their ability to modify genomic architecture, mutate genes and regulate gene expression. Accordingly, TEs are subject to tight epigenetic control during the earliest phases of embryonic development via histone and DNA methylation. Key to this process is recognition by sequence-specific RNA- and protein-based repressors. Collectively, these mediators are responsible for… CONTINUE READING
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