The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.

@article{Wang2011TheDC,
  title={The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.},
  author={Wenze Wang and Sachio Takashima and Yoshie Segawa and Masayuki Itoh and Xiuyu Shi and Su-Kyeong Hwang and Kazuki Nabeshima and Morishige Takeshita and Shinichi Hirose},
  journal={Brain research},
  year={2011},
  volume={1389},
  pages={61-70}
}
Alterations of the genes encoding α1 and α2 subunits of voltage-gated sodium channels (SCN1A, SCN2A) have been reported as causes of various types of epilepsy, most of which occur during the first year of life; as yet, however, the detailed mechanisms are unclear. We suppose that developmental changes of SCN1A and SCN2A in the human brain, which are unknown yet, may play an important role. So here, we studied the developmental changes of their corresponding proteins (Na(v)1.1 and Na(v)1.2) in… CONTINUE READING
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