The developmental basis of skeletal cell differentiation and the molecular basis of major skeletal defects.

@article{Blair2008TheDB,
  title={The developmental basis of skeletal cell differentiation and the molecular basis of major skeletal defects.},
  author={Harry C. Blair and M Shoaib Zaidi and Christopher L.-H. Huang and Li Sun},
  journal={Biological reviews of the Cambridge Philosophical Society},
  year={2008},
  volume={83 4},
  pages={401-15}
}
Vertebrate skeletal differentiation retains elements from simpler phyla, and reflects the differentiation of supporting tissues programmed by primary embryonic development. This developmental scheme is driven by homeotic genes expressed in sequence, with subdivision of skeletal primordia driven by a combination of seven transmembrane-pass receptors responding to Wnt-family signals, and by bone morphogenetic family signals that define borders of individual bones. In sea-dwelling vertebrates, an… CONTINUE READING
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