The development of the human spleen

@article{Vellguth2004TheDO,
  title={The development of the human spleen},
  author={Swantje Vellguth and B. Gaudecker and H. Müller-Hermelink},
  journal={Cell and Tissue Research},
  year={2004},
  volume={242},
  pages={579-592}
}
SummarySplenic tissue of human fetuses from the 14th to the 24th week of gestation (menstrual age) were investigated by light- and electron microscopy to describe the development of the red and white pulp in close relationship to the differentiation of the vascular tree. Special interest is focussed on the differentiation of the T-cell- and the B-cell regions and their specific stationary cells.The preliminary stage, here called the “primary vascular reticulum,” lasts up to the 14th gestational… Expand
Morphogenesis of the Spleen During the Human Embryonic Period
We aimed to observe morphological changes in the spleen from the emergence of the primordium to the end of the embryonic period using histological serial sections of 228 samples. Between CarnegieExpand
Histogenesis of spleen in human fetuses
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Even though immature RBCs and haemopoietic stem cells were detected, hemopoiesis in the spleen could not be ascertained in the present study. Expand
Fetal and early post-natal development of the human spleen: from primordial arterial B cell lobules to a non-segmented organ
TLDR
Analysis of 31 human spleens from the 11th week of gestation to the early postnatal period suggested that fetal organ development may be preliminarily divided into four stages, and the lobular architecture was no longer recognized at stage III before birth. Expand
The histological study of human fetal spleen
TLDR
The histological findings acquired in the study will be beneficial for the evaluations about the fetal spleen, and may be regarded as a preliminary study including some detailed results. Expand
Ontogeny of reticular framework of white pulp and marginal zone in human spleen: immunohistochemical studies of fetal spleens from the 17th to 40th week of gestation
TLDR
The reticular framework of the PALS, LF, and MZ is thus heterogeneous in the fetal spleen, and the development of the heterogeneity is related to the ontogeny of the B lymphocytes, Lymph follicle, and LF. Expand
Microscopic study of human spleen in different age groups
TLDR
The microscopic structure of spleen varies in different age groups, with the PALS and the white pulp showing scanty cellularity in the six month foetus, and almost uniform cellularity at full term, and the capsule thickness, trabecular network, cellularity of white pulp and red pulp, the connective tissue framework seen in the red pulp etc., showed variations in the different agegroups. Expand
Gestational age estimation in human fetuses from histogenesis of the spleen
TLDR
The time of appearance of the various features in the developing spleen may help in rough estimation of the gestational age from minimal fetal splenic tissue remains. Expand
The proportions of the white and red pulps of the human fetal spleen.
TLDR
It has been ascertained that the white pulp has been distinguished from 20th week onwards during the fetal period and reference values have been obtained about the proportions of white and red pulp areas of human fetal spleen. Expand
Distribution of laminin and types IV and III collagen in fetal, infant and adult human spleens
TLDR
The immunohistochemical distribution of the basement membrane proteins, laminin and type IV collagen, and interstitial type III collagen was investigated in 12 fetal spleens at the 15th–38th gestational weeks and inSpleens of 8 infants from term to 4 years, finding BM proteins were found to be abundantly present during the whole of development. Expand
The Phylogeny of the Spleen
TLDR
The red pulp remained essentially the same in all nonmammalian vertebrates, with a microarchitecture that concentrates blood and allows its filtration and was eventually co-opted in teleosts and mammals to develop a new function: the storage of red blood cells. Expand
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