The development of the calcifying mechanism in avian cartilage and osteoid tissue.

@article{Fell2005TheDO,
  title={The development of the calcifying mechanism in avian cartilage and osteoid tissue.},
  author={Honor B. Fell and Robert S. Robison},
  journal={The Biochemical journal},
  year={2005},
  volume={28 6},
  pages={2243-53}
}
IN the developing bone of the normal child, rat or rabbit, hypertrophy of the cartilage cells is rapidly followed by deposition of calcium salts in the cartilage matrix. If, through dietary deficiency, the deposition of calcium salts is delayed or incomplete, as in rickets, the uncalcified areas of hypertrophic cartilage can be calcified in vitro by immersing the tissues in suitable salt solutions. The uncalcified hypertrophic cartilage of these rachitic animals possesses both phosphatase and… CONTINUE READING