The development of ocular dominance columns in normal and visually deprived monkeys

@article{LeVay1980TheDO,
  title={The development of ocular dominance columns in normal and visually deprived monkeys},
  author={Simon Le Vay and Torsten N. Wiesel and David H. Hubel},
  journal={Journal of Comparative Neurology},
  year={1980},
  volume={191}
}
The main purpose of this study was to examine the normal postnatal development of ocular dominance columns in the striate cortex of the macaque monkey and to determine how this developmental process is influenced by monocular lid‐suture. The physiological pattern of ocular dominance was studied in long, tangential electrode penetrations. For anatomical demonstration of the distribution of afferents we relied principally on the transneuronal transport of [3H]proline injected into one eye, and to… 

Development of ocular dominance columns in the absence of retinal input

It is proposed that formation of ocular dominance columns relies on molecular cues present on thalamic axons, cortical cells or both, and the patterning of geniculocortical afferents resists this dramatic change in the level, source and pattern of spontaneous activity.

Ocular dominance column development: strabismus changes the spacing of adjacent columns in cat visual cortex.

  • S. Löwel
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
Observations suggest that not only the segregation of afferents into distinct columns but also the final expression of the columnar grid is influenced by visual experience, and in particular by the temporal patterning of neural activity, further evidence for the hypothesis that the development of OD columns is governed by activity-dependent self-organizing principles.

An adult-like pattern of ocular dominance columns in striate cortex of newborn monkeys prior to visual experience

  • J. HortonD. Hocking
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
Findings indicate that stimulation of the retina by light is not necessary for the development of columnar systems in the visual cortex and that ocular dominance columns, patches, and V2 stripes all are well formed before visual experience.

Timing of the Critical Period for Plasticity of Ocular Dominance Columns in Macaque Striate Cortex

The principal finding was that eyelid suture at age 1 week caused the most severe column shrinkage, implying that primate visual cortex is most vulnerable to deprivation during the first weeks of life.

Effects of visual deprivation upon the geniculocortical W‐cell pathway in the cat: Area 19 and its afferent input

In some of these monocularly deprived animals, the sizes of relay cells in the parvocellular C laminae of the dorsal lateral geniculate nucleus labeled by electrophoretic injections of horseradish peroxidase into area 19 were studied.

Effects of visual deprivation on the development of the monkey's lateral geniculate nucleus.

Although the post‐natal maturation of visual acuity in normal monkeys seems to be mainly limited by peripheral factors, deprivation does not seem to interfere substantially with physiological development of the retina or the geniculate nucleus in monkeys monocularly deprived from birth.

Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex

  • M. StrykerW. Harris
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1986
Assays indicated that retinal blockade completely blocked the formation of ocular dominance columns, unlike any of the control procedures, suggesting that the spontaneous maintained discharge of retinal ganglion cells may have an important role in the normal development of binocular connections in the visual cortex.

Ocular dominance columns and retinal projections in new world spider monkeys (Ateles ater)

Retinal projections and the degree of ocular segregation in the striate cortex were examined by transneuronal autoradiography following unilateral intraocular injections of 3H‐proline in a New World

Postnatal development of the monkey's visual system.

In both structures there are enormous functional changes after birth, but those in the LGN seem not to depend on normal visual stimulation while those inThe cortex seem crucially dependent on visual input.

Early development of ocular dominance columns.

It is proposed that ocular dominance column formation relies on the targeting of distinct axonal populations to defined locales in cortical layer 4.
...

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