The development of ocular dominance columns in normal and visually deprived monkeys

  title={The development of ocular dominance columns in normal and visually deprived monkeys},
  author={Simon Le Vay and Torsten N. Wiesel and David H. Hubel},
  journal={Journal of Comparative Neurology},
The main purpose of this study was to examine the normal postnatal development of ocular dominance columns in the striate cortex of the macaque monkey and to determine how this developmental process is influenced by monocular lid‐suture. The physiological pattern of ocular dominance was studied in long, tangential electrode penetrations. For anatomical demonstration of the distribution of afferents we relied principally on the transneuronal transport of [3H]proline injected into one eye, and to… 

Development of ocular dominance columns in the absence of retinal input

It is proposed that formation of ocular dominance columns relies on molecular cues present on thalamic axons, cortical cells or both, and the patterning of geniculocortical afferents resists this dramatic change in the level, source and pattern of spontaneous activity.

Ocular dominance column development: strabismus changes the spacing of adjacent columns in cat visual cortex.

  • S. Löwel
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
Observations suggest that not only the segregation of afferents into distinct columns but also the final expression of the columnar grid is influenced by visual experience, and in particular by the temporal patterning of neural activity, further evidence for the hypothesis that the development of OD columns is governed by activity-dependent self-organizing principles.

An adult-like pattern of ocular dominance columns in striate cortex of newborn monkeys prior to visual experience

  • J. HortonD. Hocking
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
Findings indicate that stimulation of the retina by light is not necessary for the development of columnar systems in the visual cortex and that ocular dominance columns, patches, and V2 stripes all are well formed before visual experience.

Timing of the Critical Period for Plasticity of Ocular Dominance Columns in Macaque Striate Cortex

The principal finding was that eyelid suture at age 1 week caused the most severe column shrinkage, implying that primate visual cortex is most vulnerable to deprivation during the first weeks of life.

Effects of visual deprivation upon the geniculocortical W‐cell pathway in the cat: Area 19 and its afferent input

In some of these monocularly deprived animals, the sizes of relay cells in the parvocellular C laminae of the dorsal lateral geniculate nucleus labeled by electrophoretic injections of horseradish peroxidase into area 19 were studied.

Effects of visual deprivation on the development of the monkey's lateral geniculate nucleus.

Although the post‐natal maturation of visual acuity in normal monkeys seems to be mainly limited by peripheral factors, deprivation does not seem to interfere substantially with physiological development of the retina or the geniculate nucleus in monkeys monocularly deprived from birth.

Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex

  • M. StrykerW. Harris
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1986
Assays indicated that retinal blockade completely blocked the formation of ocular dominance columns, unlike any of the control procedures, suggesting that the spontaneous maintained discharge of retinal ganglion cells may have an important role in the normal development of binocular connections in the visual cortex.

Ocular dominance columns and retinal projections in new world spider monkeys (Ateles ater)

Retinal projections and the degree of ocular segregation in the striate cortex were examined by transneuronal autoradiography following unilateral intraocular injections of 3H‐proline in a New World

Postnatal development of the monkey's visual system.

In both structures there are enormous functional changes after birth, but those in the LGN seem not to depend on normal visual stimulation while those inThe cortex seem crucially dependent on visual input.

Early development of ocular dominance columns.

It is proposed that ocular dominance column formation relies on the targeting of distinct axonal populations to defined locales in cortical layer 4.



Ocular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation.

The findings suggest that the thalamocortical projection is physically rearranged as a consequence of monocular deprivation, as has been demonstrated for layer IVc of the monkey's visual cortex.

Plasticity of ocular dominance columns in monkey striate cortex.

  • D. HubelT. WieselS. Levay
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1977
Preliminary experiments suggest that the layer IVC columns in juvenile macaque monkeys are not fully developed until some weeks after birth, which explains the critical period for deprivation effects in the layerIV columns.

Ocular dominance columns and their development in layer IV of the cat's visual cortex: A quantitative study

The distribution of geniculocortical afferents serving the left and right eyes was studied in abult cats and in kittens of various ages. Methods used were autoradiography of transneuronally

The physiological effects of monocular deprivation and their reversal in the monkey's visual cortex.

Even within layer IV c there was evidence for re‐expansion of physiologically determined ocular dominance stripes, and in all animals most cells outsidelayer IV c were orientation‐selective, and preferred orientation usually shifted from cell to cell in a regular progressive sequence.

Laminar and columnar distribution of geniculo‐cortical fibers in the macaque monkey

The laminar distribution of axon terminals in the cortex is correlated with functional differences between layers, and the IVth‐layer mosaic anatomically is demonstrated.

The pattern of ocular dominance columns in macaque visual cortex revealed by a reduced silver stain

A pattern of alternative dark and pale bands was observed in the straite cortex of the macaque monkey, observed in tangential sections stained with a reduced silver method for normal fibers.

Cells selective to binocular disparity in the cortex of newborn lambs

It is found that the visual cortex of the newborn kitten is immature and disparity selectivity appears only after exposure to a normal visual environment, and neither of these two conclusions is true of lambs.

Binocular interaction in striate cortex of kittens reared with artificial squint.

The object of the present study was to influence cortical connections by some means less drastic than covering one or both eyes, and produced a divergent strabismus by cutting one of the extraocular muscles in each of four newborn kittens.

Reversal of the physiological effects of monocular deprivation in kittens: further evidence for a sensitive period

1. It was confirmed that suturing the lids of one eye (monocular deprivation), until only 5 weeks of age, leaves virtually every neurone in the kitten's visual cortex entirely dominated by the other