The development of in vitro culture methods to characterize primary T-cell responses to drugs.

Abstract

Adverse drug reactions represent a major stumbling block to drug development and those with an immune etiology are the most difficult to predict. We have developed an in vitro T-cell priming culture method using peripheral blood from healthy volunteers to assess the allergenic potential of drugs. The drug metabolite nitroso sulfamethoxazole (SMX-NO) was… (More)
DOI: 10.1093/toxsci/kfs080

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