The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats.

@article{Chandrasekar2007TheDO,
  title={The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats.},
  author={Durairaj Chandrasekar and Ramakrishna Sistla and Farhan Jalees Ahmad and Roop Kishan Khar and Prakash Vamanrao Diwan},
  journal={Biomaterials},
  year={2007},
  volume={28 3},
  pages={504-12}
}
The aim of this study was to synthesize folate-dendrimer conjugates as suitable vehicle for site specific delivery of anti-arthritic drug (indomethacin) to inflammatory regions and to determine its targeting efficiency, biodistribution in adjuvant induced arthritic rats. Folic acid was coupled to the surface amino groups of G4-PAMAM dendrimer (G4D) via a carbodiimide reaction and loaded with indomethacin. The conjugates were characterized by (1)H-NMR and IR spectroscopy. The drug content and… CONTINUE READING

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