The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats.

Abstract

The aim of this study was to synthesize folate-dendrimer conjugates as suitable vehicle for site specific delivery of anti-arthritic drug (indomethacin) to inflammatory regions and to determine its targeting efficiency, biodistribution in adjuvant induced arthritic rats. Folic acid was coupled to the surface amino groups of G4-PAMAM dendrimer (G4D) via a… (More)

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@article{Chandrasekar2007TheDO, title={The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats.}, author={Durairaj Chandrasekar and Ramakrishna Sistla and Farhan Ahmad and Roop Kishen Khar and Prakash Vaman Rao Diwan}, journal={Biomaterials}, year={2007}, volume={28 3}, pages={504-12} }