The development of chronic mechanical hyperalgesia, autotomy and collateral sprouting following sciatic nerve section in rat.

@article{Kingery1989TheDO,
  title={The development of chronic mechanical hyperalgesia, autotomy and collateral sprouting following sciatic nerve section in rat.},
  author={Wade S. Kingery and J A Vallin},
  journal={Pain},
  year={1989},
  volume={38 3},
  pages={321-32}
}
The development of mechanical hyperalgesia over the tarsometatarsal joints subsequent to chronic sciatic section was studied in rats. Mechanical thresholds began to drop within 7 days of sciatic section and continued to decline for 2-3 weeks, resulting in significant hyperalgesia over the original saphenous and sciatic border zones lasting up to 310 days. Contralateral hyperalgesia, which is seen in tissue injury mechanical hyperalgesia, failed to develop. Collateral sprouting of high-threshold… CONTINUE READING