The development of behavioral sensitization to apomorphine is blocked by MK-801.

@article{Druhan1993TheDO,
  title={The development of behavioral sensitization to apomorphine is blocked by MK-801.},
  author={J P Druhan and Alfred Jakob and Jane Stewart},
  journal={European journal of pharmacology},
  year={1993},
  volume={243 1},
  pages={73-7}
}
The effects of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), on the development of sensitization to the mixed dopamine receptor agonist, apomorphine were examined. Rats pretreated with MK-801 (0.25 mg/kg) prior to 2.0 mg/kg apomorphine failed to show a progressive sensitization to the activating effect of apomorphine across six preexposure sessions, nor did they show enhanced activity relative to control rats in response to 0.5 mg/kg apomorphine, given alone, during a… CONTINUE READING

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