The development of artemisinin resistance in malaria: reasons and solutions

@article{Chrubasik2010TheDO,
  title={The development of artemisinin resistance in malaria: reasons and solutions},
  author={C. Chrubasik and R. Jacobson},
  journal={Phytotherapy Research},
  year={2010},
  volume={24}
}
Despite world‐wide efforts in fighting malaria, this mosquito‐borne infectious disease is a huge burden for the population, especially in tropical and subtropical areas. The WHO recommends artemisinin‐based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria. However, artemisinin resistance cannot now be ignored. Factors affecting the development of artemisinin resistance include uncontrolled use of artemisinin‐based combination therapy (ACT), mobile populations… Expand
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The assessment of serum urea, creatinine and bilirubin levels in malaria infested wistar rats treated with the crude extract of Artemisia annua and artemisinin combination therapy (ACT) was… Expand
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References

SHOWING 1-10 OF 13 REFERENCES
Evidence of artemisinin-resistant malaria in western Cambodia.
TLDR
Artemisinins are potent and rapidly acting antimalarial drugs, and their widespread use for treating patients with Plasmodium falciparum malaria raises the question of emerging drug resistance. Expand
Advances in global biotechnology and local resources to treat malaria.
The global campaign toward malaria eradication has received a tremendous boost with the addition of artemisinin compounds to the therapeutic armament. Artemisinin drugs are now being recommended in… Expand
Artemisia annua as a self-reliant treatment for malaria in developing countries.
TLDR
A short history of the malaria disease, the people forming a high risk group and the botanical aspects of A. annua, the discovery and development of artemisinins from Artemisia annua have provided a new class of highly effective antimalarials, and the use of ART and its derivatives for the treatment of malaria is provided. Expand
Simple Field Assays to Check Quality of Current Artemisinin-Based Antimalarial Combination Formulations
TLDR
Two novel colour reaction assays requiring no specialist training have successfully resulted in detecting two counterfeit drugs within a small scale screening survey of over 100 declared artemisinin-containing drugs collected from various Asian and African countries. Expand
Artemisinin-based combination therapy for treating uncomplicated malaria.
TLDR
Dihydroartemisinin-piperaquine is another effective first-line treatment for P. falciparum malaria and ACTs with long half-lives may provide some benefit, while the performance of the non-ACT (amodiaquine plus sulfadoxine-pyrimethamine) falls below WHO recommendations for first- line therapy in parts of Africa. Expand
Spread of anti-malarial drug resistance: Mathematical model with implications for ACT drug policies
TLDR
This model can be a useful tool to inform the design of treatment policies, particularly at a time when ACT has been endorsed by WHO as first-line treatment for falciparum malaria worldwide. Expand
The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review.
TLDR
The ongoing situation of human malaria in the Brazilian Amazon, where it is endemic causing over 610,000 new acute cases yearly, is discussed, a number which is on the increase and new antimalarial drugs are urgently needed. Expand
Comparative study of the in vitro sensitivity of Plasmodium falciparum to artemisinin in two border areas of Thailand.
TLDR
The lower sensitivity of Plasmodium falciparum to mefloquine in Mae Sot may play a minor (but amplifying) role, as the activities of artemisinin and meFLoquine show a significant correlation. Expand
Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6
TLDR
A rise in resistance to artemisinin derivatives in field isolates indicates the need for increased vigilance and a coordinated and rapid deployment of drug combinations. Expand
WITHDRAWN: Vaccines for preventing malaria.
TLDR
There is no evidence for protection by SPf66 vaccines against P. falciparum malaria in Africa, and further research with SPf 66 vaccines in South America or with new formulations ofSPf66 may be justified. Expand
...
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