The development of androgen-independent prostate cancer

@article{Feldman2001TheDO,
  title={The development of androgen-independent prostate cancer},
  author={Brian J Feldman and David Feldman},
  journal={Nature Reviews Cancer},
  year={2001},
  volume={1},
  pages={34-45}
}
The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress. Cancers that are not cured by surgery eventually become androgen independent, rendering anti-androgen therapy ineffective. But how does androgen independence arise? We predict that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present… 
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TLDR
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TLDR
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Upregulation of the Androgen Receptor during Prostate Cancer Progression
TLDR
It is reported that the androgen receptor is consistently upregulated as hormone sensitive prostate cancer changes to a hormone refractory state and that this change is intricately involved during the development of resistance to androgen ablation therapy.
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TLDR
This review will try to summarize the knowledge of the genetic events governing the conversion to androgen independency in prostate tumorigenesis.
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TLDR
It is estimated that during 2005, ∼232,090 new cases of prostate cancer will be diagnosed in the United States and 30,350 menwill be diagnosed with prostate cancer.
Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivity
TLDR
The role of the androgen receptor in the progression of androgen‐dependent human prostate cancer cells to androgen-independent and androgens‐insensitive phenotypes is unclear.
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