The development of androgen-independent prostate cancer

@article{Feldman2001TheDO,
  title={The development of androgen-independent prostate cancer},
  author={Brian J. Feldman and David Feldman},
  journal={Nature Reviews Cancer},
  year={2001},
  volume={1},
  pages={34-45}
}
The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress. Cancers that are not cured by surgery eventually become androgen independent, rendering anti-androgen therapy ineffective. But how does androgen independence arise? We predict that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present… CONTINUE READING
Highly Influential
This paper has highly influenced 64 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 922 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 112 references

Testbook of Endocrinology 9th edn

J. E. Griffin, Wilson, J. D. in Williams
1998
View 5 Excerpts
Highly Influenced

A mechanism for androgen receptormediated prostate cancer recurrence after androgen deprivation therapy

Gregory, W C.
Cancer Res • 2001

Collocation of androgen receptor gene mutations in prostate cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2001

Crystallographic structures of the ligandbinding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

Sack, S J.
Proc. Natl Acad. Sci. USA • 2001

Similar Papers

Loading similar papers…