The development of an alginate/polycaprolactone composite scaffold for in situ transfection application.

@article{Hu2018TheDO,
  title={The development of an alginate/polycaprolactone composite scaffold for in situ transfection application.},
  author={W Hu and Yun-Chung Wu and Zhe-Chen Hu},
  journal={Carbohydrate polymers},
  year={2018},
  volume={183},
  pages={29-36}
}
Alginate and polycaprolactone (PCL) were coelectrospun using a dual-jet system to prepare composite nanofibers in defined ratios, and hence both chemical properties and hydrophobicity of scaffolds can be manipulated. These nanofibers were applied in gene immobilization: positively charged polyethyleneimine (PEI)/DNA polyplexes were adsorbed onto anionic alginate fibers, and the higher ratios of alginate resulted in the more immobilized nonviral vectors. Through the incorporation of PCL… CONTINUE READING