The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia.

@article{Blanco2010TheDO,
  title={The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia.},
  author={Teresa Mortera Blanco and Athanasios Mantalaris and Alexander Bismarck and Nicki Panoskaltsis},
  journal={Biomaterials},
  year={2010},
  volume={31 8},
  pages={2243-51}
}
Acute myeloid leukaemia (AML) is a cancer of haematopoietic cells that develops in three-dimensional (3-D) bone marrow niches in vivo. The study of AML has been hampered by lack of appropriate ex vivo models that mimic this microenvironment. We hypothesised that fabrication and optimisation of suitable biomimetic scaffolds for culturing leukaemic cells ex vivo might facilitate the study of AML in its native 3-D niche. We evaluated the growth of three leukaemia subtype-specific cell lines, K-562… CONTINUE READING

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