The development of a novel wound healing material, silk-elastin sponge.

Abstract

Silk-elastin is a recombinant protein polymer with repeating units of silk and elastin blocks. This novel wound healing promoting material has the ability to self-assemble from a liquid to a gel. We have already reported that an aqueous solution of silk-elastin has the potential to accelerate wound healing; however, there are several problems in applying silk-elastin in the clinical setting. To solve these problems, we developed a silk-elastin sponge that is easy to use in the clinical setting. In the present study, we examined whether the wound healing effect of the silk-elastin sponge is equal to the aqueous solution of silk-elastin in vivo. The granulation tissue formation promoting effect of the silk-elastin sponge was equal to that of the aqueous solution the silk-elastin, as after application to the wound surface, the sponge was absorbed and dissolved by the exudate. At body temperature the silk-elastin then formed temperature gel. The silk-elastin gel that was obtained contained abundant cytokines from the exudate. We believe that silk-elastin sponge can be applied to various wounds that are difficult to treat with the aqueous solution.

DOI: 10.1080/09205063.2017.1382829

Cite this paper

@article{Kawabata2017TheDO, title={The development of a novel wound healing material, silk-elastin sponge.}, author={Shingo Kawabata and Katsuya Kawai and Satoshi Somamoto and Kazuo Noda and Yoshitaka Matsuura and Yoko Nakamura and Shigehiko Suzuki}, journal={Journal of biomaterials science. Polymer edition}, year={2017}, volume={28 18}, pages={2143-2153} }