The development of T cells from stem cells in mice and humans

  title={The development of T cells from stem cells in mice and humans},
  author={Farbod Famili and Anna-Sophia Wiekmeijer and Frank J T Staal},
  booktitle={Future science OA},
T cells develop from hematopoietic stem cells in the specialized microenvironment of the thymus. The main transcriptional players of T-cell differentiation such as Notch, Tcf-1, Gata3 and Bcl11b have been identified, but their role and regulation are not yet completely understood. In humans, functional experiments on T-cell development have traditionally been rather difficult to perform, but novel in vitro culture systems and in vivo xenograft models have allowed detailed studies on human T… CONTINUE READING
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Development of a diverse human T cell repertoire despite stringent restriction of hematopoietic clonality in the thymus

  • MH Brugman, AS Wiekmeijer, M Eggermond
  • Proc. Natl Acad. Sci. USA 112(44),
  • 2015

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