The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.

@article{Heward1999TheDO,
  title={The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.},
  author={Joanne M. Heward and Amit Allahabadia and Mary Armitage and Andrew T Hattersley and Paul M. Dodson and Kenneth Macleod and Jackie D Carr-Smith and Jacqueline Daykin and A Daly and Michael C. Sheppard and Roger L. Holder and Anthony Barnett and Jayne A. Franklyn and Stephen C. L. Gough},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 7},
  pages={2398-401}
}
Case-control studies suggest that the CTLA-4 gene may be a susceptibility locus for Graves' disease. The previously reported A/G polymorphism at position 49 in exon 1 of the CTLA-4 gene was, therefore, investigated in a case-control (n = 743) and family-based (n = 179) dataset of white Caucasian subjects with Graves' disease. The relationship between CTLA-4 genotype and severity of thyroid dysfunction at diagnosis was also investigated. An increase in frequency of the G (alanine) allele was… CONTINUE READING

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