The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva

@article{Amara2021TheDA,
  title={The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite {\ss}-d-N4-hydroxycytidine in human plasma and saliva},
  author={Alieu Amara and Sujan Dilly Penchala and Laura J. Else and Colin Hale and Richard J Fitzgerald and Lauren Walker and Rebecca L. Lyons and Tom Fletcher and Saye H. Khoo},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2021},
  volume={206},
  pages={114356 - 114356}
}

Figures and Tables from this paper

Pharmacokinetics of β-d-N4-hydroxycytidine, the active metabolite of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection
TLDR
Characterised the pharmacokinetics of NHC in saliva, nasal secretions and tears of patients enrolled in the phase I AGILE trial to understand its potential in preventing infection and transmission and have important implications for prophylactic coverage.

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