The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes

@inproceedings{Shields2011TheDA,
  title={The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes},
  author={Beverley M Shields and Timothy J McDonald and Sian Ellard and M J Campbell and Christopher J. Hyde and Andrew T Hattersley},
  booktitle={Diabetologia},
  year={2011}
}
Diagnosing MODY is difficult. To date, selection for molecular genetic testing for MODY has used discrete cut-offs of limited clinical characteristics with varying sensitivity and specificity. We aimed to use multiple, weighted, clinical criteria to determine an individual’s probability of having MODY, as a crucial tool for rational genetic testing. We developed prediction models using logistic regression on data from 1,191 patients with MODY (n = 594), type 1 diabetes (n = 278) and type 2… CONTINUE READING

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of young people

  • BM Shields, S Hicks, MH Shepherd, K Colclough, AT Hattersley, S Ellard
  • 2010

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