The development and function of follicular helper T cells in immune responses

@article{Chen2012TheDA,
  title={The development and function of follicular helper T cells in immune responses},
  author={Maogen Chen and Zong-wei Guo and Weiqiang Ju and Bernhard Ryffel and Xiao-shun He and Song Guo Zheng},
  journal={Cellular and Molecular Immunology},
  year={2012},
  volume={9},
  pages={375-379}
}
Follicular helper T cells (Tfh) have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development… CONTINUE READING

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