The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

@article{Lthje2012TheDA,
  title={The development and fate of follicular helper T cells defined by an IL-21 reporter mouse},
  author={Katja L{\"u}thje and Axel Kallies and Yoko Shimohakamada and Gabrielle T. Belz and Amanda Light and David M Tarlinton and Stephen L Nutt},
  journal={Nature Immunology},
  year={2012},
  volume={13},
  pages={491-498}
}
Germinal centers require CD4+ follicular helper T cells (TFH cells), whose hallmark is expression of the transcriptional repressor Bcl-6, the chemokine receptor CXCR5 and interleukin 21 (IL-21). To track the development and fate of TFH cells, we generated an IL-21 reporter mouse by introducing sequence encoding green fluorescent protein (GFP) into the Il21 locus; these mice had expression of IL-21–GFP in CD4+CXCR5+PD-1+ TFH cells. IL-21–GFP+ TFH cells were multifunctional helper cells that… CONTINUE READING
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