The development and expression of locomotor sensitization to nicotine in the presence of ibogaine.

@article{Zubaran2000TheDA,
  title={The development and expression of locomotor sensitization to nicotine in the presence of ibogaine.},
  author={Carlos Zubaran and Mohammed Shoaib and I P Stolerman},
  journal={Behavioural pharmacology},
  year={2000},
  volume={11 5},
  pages={431-6}
}
Ibogaine is a naturally occurring psychoactive alkaloid with claimed efficacy in the treatment of certain drug addictions, including nicotine. It has been reported to be a non-competitive blocker of nicotinic receptors, with a potent inhibitory action on nicotinic acetylcholine receptor-mediated catecholamine release. We have investigated the effect of different doses of ibogaine on the development and expression of sensitization to the locomotor stimulant effect of nicotine in rats, a… CONTINUE READING