The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate.

@article{Horimoto2006TheDA,
  title={The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate.},
  author={Taisuke Horimoto and Atsushi Takada and Ken Ichi Fujii and Hideo Goto and Masato Hatta and Shinji Watanabe and Kiyoko Iwatsuki-Horimoto and Mutsumi Bunkyo-ku Ito and Yuko Tagawa-Sakai and Shinya Yamada and Hirotoshi Ito and Toshihiro Ito and Masanori Imai and Shigeyuki Tsunashimahigashi Mansion Itamura and Takato Odagiri and Masato Tashiro and Wilina Wei Ling Lim and Yi Guan and Malik Peiris and Yoshihiro Kawaoka},
  journal={Vaccine},
  year={2006},
  volume={24 17},
  pages={
          3669-76
        }
}
The pandemic threat posed by highly pathogenic H5N1 influenza A viruses has created an urgent need for vaccines to protect against H5 virus infection. Because pathogenic viruses grow poorly in chicken eggs and their virulence poses a biohazard to vaccine producers, avirulent viruses produced by reverse genetics have become the preferred basis for vaccine production. Here, we investigated two key characteristics of potential H5 vaccine candidates: the hemaggutinin (HA) cleavage site sequence and… CONTINUE READING
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