The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells.

@article{Chen2012TheDD,
  title={The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells.},
  author={Qingguo Chen and Shanthini Mahendrasingam and Jacqueline A Tickle and Carole M. Hackney and David N Furness and Robert Fettiplace},
  journal={The European journal of neuroscience},
  year={2012},
  volume={36 3},
  pages={2302-10}
}
Calcium is tightly regulated in cochlear outer hair cells (OHCs). It enters mainly via mechanotransducer (MT) channels and is extruded by the plasma membrane calcium ATPase (PMCA)2 isoform of the PMCA, mutations in which cause hearing loss. To assess how pump expression matches the demands of Ca(2+) homeostasis, the distribution of PMCA2 at different cochlear locations during development was quantified using immunofluorescence and post-embedding immunogold labeling. The PMCA2 isoform was… CONTINUE READING