The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans.

@article{Kowalski2011TheDE,
  title={The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans.},
  author={Jennifer R. Kowalski and Caroline Lund Dahlberg and Peter Juo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 4},
  pages={1341-54}
}
Ubiquitin-mediated endocytosis and post-endocytic trafficking of glutamate receptors control their synaptic abundance and are implicated in modulating synaptic strength. Ubiquitination is a reversible modification, but the identities and specific functions of deubiquitinating enzymes in the nervous system are lacking. Here, we show that the deubiquitinating enzyme ubiquitin-specific protease-46 (USP-46) regulates the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of… CONTINUE READING

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