The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-β signalling

@article{Wicks2005TheDE,
  title={The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-β signalling},
  author={Stephen J Wicks and Katherine Haros and Marjorie Maillard and Ling Song and Robert E Cohen and Peter ten Dijke and Andrew D. Chantry},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={8080-8084}
}
Disruption of components in the transforming growth factor-β (TGF-β) signalling cascade is a common occurrence in human cancers. TGF-β pathway activation is accomplished via serine/threonine kinase receptors and intracellular Smad transcription factors. A key regulatory step involves specific ubiquitination by Smurfs that mediate the proteasomal degradation of Smads and/or receptors. Here, we report a novel interaction between Smads and ubiquitin C-terminal hydrolase UCH37, a deubiquitinating… CONTINUE READING