The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin.

  title={The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin.},
  author={Shinichiro Taya and Toshiyoshi Yamamoto and Masami Kanai-Azuma and Stephen A Wood and Kozo Kaibuchi},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={4 12},
BACKGROUND In the ubiquitin-proteasome pathway, the ubiquitinated substrates either undergo degradation by the proteasome or stabilization through the action of the deubiquitinating enzyme. We have previously found that the deubiquitinating enzyme Fam is colocalized with AF-6, one of the effectors of the Ras small GTPase, at cell-cell contact sites in epithelial cells and interacts with AF-6 in vivo and in vitro. Fam has deubiquitinating activity in vitro and prevents the ubiquitination of AF-6… CONTINUE READING

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