The determination of the local cerebral glucose utilization with the 2-deoxyglucose method

@article{Wree1988TheDO,
  title={The determination of the local cerebral glucose utilization with the 2-deoxyglucose method},
  author={Andreas Wree and Axel Schleicher},
  journal={Histochemistry},
  year={1988},
  volume={90},
  pages={109-121}
}
In the adult mammalian brain, the energy metabolism is almost entirely dependent on glucose. Furthermore, a close relationship between the energy metabolism and the functional activity could be shown. Thus, the functional activity of the brain or parts thereof can be quantified by measuring the cerebral metabolic rate for glucose. Studying in vivo the fate of a radioactive labeled analogue of glucose, the 2-deoxy-d-[1-14C]glucose, and using quantitative autoradiographic techniques, it is… CONTINUE READING

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The radioactive deoxyglucose method: Theory, procedure, and application for the local cerebral glucose utilization in the central nervous system

  • L Sokoloff
  • Adv Neurochem
  • 1982
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