The determination of hydroxydopamines and other trace amines in the urine of Parkinsonian patients and normal controls

@article{Andrew1993TheDO,
  title={The determination of hydroxydopamines and other trace amines in the urine of Parkinsonian patients and normal controls},
  author={Ruth Andrew and Dr. D. G. Watson and S. A. Best and John Midgley and H. Wenlong and Richard K. H. Petty},
  journal={Neurochemical Research},
  year={1993},
  volume={18},
  pages={1175-1177}
}
5- and 6-Hydroxydopamine, which we had earlier identified as naturally occurring amines in human urine, were quantified in Parkinson's patients treated with L-DOPA, Parkinson's patients whose treatment did not include L-DOPA and in age matched controls. Analysis was carried out by GCMS of the ditrifluoromethylbenzoyl-trimethylsilyl (DTFMB-TMS) derivatives of the compounds. The concentrations of 5- and 6-hydroxydopamine in the urine of DOPA treated Parkinson's patients were significantly higher… CONTINUE READING
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