The determination of S-nitrosothiols in biological samples--procedures, problems and precautions.

@article{Bramanti2011TheDO,
  title={The determination of S-nitrosothiols in biological samples--procedures, problems and precautions.},
  author={Emilia Bramanti and Valeria Weiss Angeli and Aldo Paolicchi and Alfonso Pompella},
  journal={Life sciences},
  year={2011},
  volume={88 3-4},
  pages={126-9}
}
Despite the considerable number of published studies in the field of S-nitrosothiols (RSNO), the determination of these compounds in biological samples still represents an analytical challenge, due to several technical obstacles and often long sample preparation procedures. Other problems derive from the intrinsic lability of RSNO and the absence of certified reference material, analytically validated methods or suitable internal standards. Also, thiols and nitrites are usually present at high… CONTINUE READING