The determination and application of fixed-dose analgesic combinations for treating multimodal pain.

@article{Raffa2010TheDA,
  title={The determination and application of fixed-dose analgesic combinations for treating multimodal pain.},
  author={Robert B Raffa and J V Pergolizzi and Ronald J. Tallarida},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2010},
  volume={11 8},
  pages={
          701-9
        }
}
  • Robert B Raffa, J V Pergolizzi, Ronald J. Tallarida
  • Published in
    The journal of pain…
    2010
  • Medicine
  • UNLABELLED When the pathophysiology of a medical condition is multimodal, ie, related to multiple physiological causes or mediated by multiple pathways, the optimal strategy can be to use a drug or a combination of drugs that contribute multiple mechanisms to the therapeutic endpoint. In such situations, a rational multimodal approach can also result in the fewest adverse effects. We discuss the quantitative analysis of multimodal action using the treatment of pain as a practical example and… CONTINUE READING

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