The detection of residual acute lymphoblastic leukemia cells with immunologic methods and polymerase chain reaction: a comparative study.

@article{Campana1990TheDO,
  title={The detection of residual acute lymphoblastic leukemia cells with immunologic methods and polymerase chain reaction: a comparative study.},
  author={Dario Campana and Shohei Yokota and Elaine Coustan-Smith and T E Hansen-Hagge and George Janossy and Claus Rainer Bartram},
  journal={Leukemia},
  year={1990},
  volume={4 9},
  pages={609-14}
}
In this study we applied double color immunofluorescence analysis and polymerase chain reaction (PCR) amplification of rearranged TCR delta genes for detecting residual leukemia in the posttreatment bone marrow (BM) samples taken from four patients in morphological remission. In three of these patients (nos. 1-3; T-ALL) a combination of CD3 and anti-TdT antibodies (Abs) was used to identify residual blasts while in patient 4 (B lineage ALL) the combination CD13/TdT served to detect residual… CONTINUE READING

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