The detection of phenotypic differences in the metabolic plasma profile of three strains of Zucker rats at 20 weeks of age using ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry.

@article{Plumb2006TheDO,
  title={The detection of phenotypic differences in the metabolic plasma profile of three strains of Zucker rats at 20 weeks of age using ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry.},
  author={Robert S. Plumb and Kelly A Johnson and Paul D. Rainville and John P. Shockcor and Rebecca C Williams and Jennifer H. Granger and Ian D Wilson},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2006},
  volume={20 19},
  pages={2800-6}
}
Analysis of biological fluids using ultra-performance liquid chromatography/mass spectrometry (UPLC/MS) (metabonomics) can allow new insights to be gained into disease processes, with advances in chromatographic techniques enabling the detection of thousands of metabolites. In this work metabonomics has been used to investigate the metabolic processes involved in type II diabetes in the Zucker obese rat. Plasma was analyzed from three different strains, the Zucker (fa/fa) obese, Zucker lean and… CONTINUE READING