The detection of micrometastases in the peripheral blood and bone marrow of patients with breast cancer using immunohistochemistry and reverse transcriptase polymerase chain reaction for keratin 19.

@article{Schoenfeld1997TheDO,
  title={The detection of micrometastases in the peripheral blood and bone marrow of patients with breast cancer using immunohistochemistry and reverse transcriptase polymerase chain reaction for keratin 19.},
  author={Ariel Schoenfeld and K. Kruger and Jenny Gomm and H. Dudley Sinnett and J C Gazet and Natalie Sacks and Hans Georg Bender and Yunus A. Luqmani and R C Coombes},
  journal={European journal of cancer},
  year={1997},
  volume={33 6},
  pages={854-61}
}
The aim of this study was to determine whether reverse transcriptase polymerase chain reaction (RT-PCR) for keratin 19 (K19) provides additional information when combined with immunohistochemistry when used to detect micrometastases in blood and bone marrow in patients with primary breast cancer. We studied 78 patients with breast cancer who had no evidence of distant metastases. We collected blood and bone marrow, separated the mononuclear fraction and carried out RT-PCR and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

Clinical relevance of cancer stem cells in bone marrow of early breast cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology • 2013

Assessment of the effect of surgery on the kinetics of circulating tumour cells in patients with operable breast cancer based on cytokeratin-19 mRNA detection.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology • 2011
View 1 Excerpt

Circulating cancer cells.

Annals of oncology : official journal of the European Society for Medical Oncology • 2010

Similar Papers

Loading similar papers…